You've made the problem clearer, butI don't understand the geometric picture yet. The product is a disk, but this is a lining process. I don't see how the two are related. Can you give a link to a picture of this type of product and its mold?
You need to clarify what factors you intend to control.
For example, suppose you make a new mold and your data predicts it will work best at a given temperature and pressure, do you intend only to operate it at that temperature and pressure? Presumably, if your data shows the mold works best with Person A operating Machine M then you won't be able have Person A and machine M be the only ones that use the mold.
If you don't intend to control variables, there can still be some benefit to recording them. However, the most important variables are those that can be controlled.
Even if you can control all the environmental variables, I don't understand how this will help you design a new mold. Isn't the design based on how the properties of the mold affect the final product? - it's dimensions? - its specific heat? etc.
A simple sort of "what sample size?" problem go like this. We want to estimate the mean value of a variable and we want a 95% probability that the estimated value we get from the data will be within plus or minus some given number of the actual value. How many independent random samples should we take to estimate the mean value? This type of problem is not hard to solve.
When you have a question like "What sample size do I need to estimate the mean value of D as a function of variables, X,Y,Z?" you are asking a much more complicated question. If you try to force this problem into the pattern of the previous paragraph, you'll get an answer that says you need a huge number of samples. For example, you would need a certain number of samples for the condition: Operator: Person A Temperature:200 Machine: M Pressure 97 and then you would need a certain number of samples for slightly different conditions such as Operator Person A Temperature 205 Machine M Pressure 93.
A practical approach is to assume the function D = f(X,Y,Z) is from a family of functions that are defined by a few parameters. Then the problem is to estimate a few parameters instead of estimating the value of an unknown type of function at the many possible combinations of variable values.
You haven't revealed what variable or variables make one mold (or final product) better than another. You might be dealing with several aspects instead of one number D.
There is an engineering discipline that analyzes problems that resemble yours. It is called "The Design Of Experiments". That field of study is much narrower that its grand name suggests. Like most engineering versions of statistical theories, I find the jargon it uses repulsive. However, it is one thing we should look at. Perhaps you can find a local consultant in "The Design Of Experiments".