How Can I Grow Crystals of My Platinum Complexes?

  • Thread starter Thread starter KarolinaPL
  • Start date Start date
AI Thread Summary
The discussion centers on the challenges of growing crystals from platinum(II) complexes, specifically derivatives of cisplatin with bulky hydrophobic amine ligands. The primary issue is the solubility of these complexes, which are poorly soluble in water but soluble in DMF, a solvent that has not yielded successful crystallization. Acetonitrile was also attempted without success. Participants suggest exploring a wider range of solvents beyond DMF and acetonitrile, including DMSO, methanol, hexane, acetone, and dichloromethane, as well as more complex solvents like toluene and pyridine. The conversation emphasizes the importance of experimenting with various solvents and methods for recrystallization to achieve successful crystal growth. Additionally, references to recent methods for crystallizing similar complexes are provided for further exploration.
KarolinaPL
Messages
9
Reaction score
0
Hi! i prepare different platinum(II) complexes, derivatves of cisplatin, where one or two ammine ligands are substituted by bulky hydrophobc amine... i would like to grow crystals, but i have a problem with it... the solvent... they are usually poor soluble in water, good soluble in e.g. DMF... but DMF didnt work for crystals. In similar case, they used acetonitrile, i tried as well, it didnt work...
 
Last edited:
Chemistry news on Phys.org
KarolinaPL said:
Hi! i prepare different platinum(II) complexes, derivatves of cisplatin, where one or two ammine ligands are substituted by bulky hydrophobc amine... i would like to grow crystals, but i have a problem with it... the solvent... they are usually poor soluble in water, good soluble in e.g. DMF... but DMF didnt work for crystals. In similar case, they used acetonitrile, i tried as well, it didnt work...

How, specifically, did those soluble solvents not work? Did the molecule decompose? Did it become some amorphous gel? Are DMF and acetonitrile the only solvent you have tried? Typically, searching for solvents for recrystallization require you to try out all the available solvents. DMSO, methanol, hexane, acetone, dimethylether, dichloromethane, chloroform, etc. There are lots of other solvents out there. If these relatively safe solvents don't work, try toluene, benzene, pyridine, etc.I can also suggest you several recrystallization methods you can try, but I would like to know above information first.
 

Thread 'Solubility of MgSO47H2O in water'

It seems like a simple enough question: what is the solubility of epsom salt in water at 20°C? A graph or table showing how it varies with temperature would be a bonus. But upon searching the internet I have been unable to determine this with confidence. Wikipedia gives the value of 113g/100ml. But other sources disagree and I can't find a definitive source for the information. I even asked chatgpt but it couldn't be sure either. I thought, naively, that this would be easy to look up without...
View full post »

Thread 'Why does having 8 valence electrons make an element inert?'

I was introduced to the Octet Rule recently and make me wonder, why does 8 valence electrons or a full p orbital always make an element inert? What is so special with a full p orbital? Like take Calcium for an example, its outer orbital is filled but its only the s orbital thats filled so its still reactive not so much as the Alkaline metals but still pretty reactive. Can someone explain it to me? Thanks!!
View full post »

Similar threads

How can I successfully grow high-quality KDP crystals?
Replies
3
Views
3K
Admissions How Can I Enhance My Statement of Purpose for a PhD Program?
Replies
5
Views
3K
How can I improve my performance in school?
Replies
5
Views
6K

Hot Threads

Recent Insights

Back
Top