The biggest issue is that the Schrödinger equation (the fundamental equation of QM) is not lorentz-invariant. This means that the equations of QM are different for two observers moving at a relative velocity to one another---which is clearly unacceptable for relativity.
Additionally, QM always maintains a conserved particle number. From relativity we learn that [tex]E=\gamma mc^2[/tex], and thus whenever the energy of a system (e.g. a pair of photons) is greater than the rest mass energy of another particle-pair (e.g. electron-positron pair), we can expect some probability of particle creation.