The discussion centers on how the size of the universe is calculated, particularly focusing on the observable universe versus the concept of an infinite universe. Participants clarify that when people refer to the "size of the universe," they typically mean the observable universe. Various comparisons are made to illustrate the vast differences in scale, such as the relationship between atomic sizes and larger cosmic structures. The Planck length and hydrogen atom sizes are mentioned to emphasize the significant differences in scale, with some suggesting creative analogies to visualize these concepts. Ultimately, the conversation highlights the complexities involved in understanding and measuring the universe's size.