How does chloral hydrate affect GABAnergism?

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Chloral hydrate is suggested to induce sleep through GABA agonism, but the specifics of its mechanism remain unclear. The inquiry focuses on whether chloral hydrate leads to increased intracellular GABA levels in post-synaptic neurons and if this could result in tolerance due to compensatory responses. Such responses may involve a reduction in the number of GABA receptors on the cell body as a reaction to elevated neurotransmitter stimulation. Additionally, the discussion raises questions about the impact of chloral hydrate on GABA autoreceptors located on pre-synaptic neurons, which could further influence its effects and potential for tolerance. Understanding these interactions is crucial for assessing the long-term implications of chloral hydrate use for individuals.
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After some poking around I found this article<sup>1</sup> suggesting that chloral hydrate somehow has a hypnotic (sleep inducing) effect via GABA agonism, but this isn't very specific.

What I need to know is if it causes a deluge of intracellular GABAnergism in the post-synaptic (dendritic) neurons. Will it eventually result in a tolerance to chloral hydrate and GABA via the compensatory response whereby an abnormally high level of intracellular neurotransmitter stimulation (whether it is caused by the neurotransmitter or another chemical that happens to stimulates the receptor) causes the cell to reduce the number of neuroreceptors for the elevated neurotransmitter type on the cell body?

I need to know for my family.

<sup>1</sup>http://www.ncbi.nlm.nih.gov/pubmed/17557503
 
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