Microgravity significantly impacts human physiology, particularly the cardiovascular system and heart functioning. One major effect is the weakening of bones due to loss of bone mass, a serious concern for astronauts. Additionally, muscles, including those in the heart, weaken from disuse in a microgravity environment. This reduction in muscle strength can lead to challenges for astronauts upon returning to Earth, as their hearts may struggle to pump blood effectively after adapting to the lower demands of microgravity. Ongoing studies on the International Space Station aim to gather more data on these effects and their implications for human health in space.