How Does Non-Ergodicity Impact the Resting State of Living Cells?

AI Thread Summary
The discussion focuses on the physical analysis of living cells, emphasizing the significance of non-ergodicity in understanding their resting state. The resting state, as described by Gilbert Ling, is characterized by lower entropy due to bound quasi-crystallized water, which is crucial for cellular energy storage. The authors propose a new thermodynamic approach that aligns with Ling's model while incorporating non-ergodicity to explain physiological phenomena. However, skepticism exists regarding the concept of structured water, which lacks empirical support despite its prominence in discussions about cellular dynamics. The conversation highlights the need for further exploration and validation of these theories within the context of biological physics.
Vladimir Matveev
Messages
23
Reaction score
7
Dear Colleagues,

I would like to submit to your court the article in which we attempt a physical analysis of living matter. Biology is a very difficult field for physics as a result errors are very likely. We would appreciate guidance on possible errors.

Prokhorenko DV and Matveev VV. The significance of non-ergodic property of statistical mechanics systems for understanding resting state of a living cell. British Journal of Mathematics & Computer Science. 2011;1(2):46-86.Abstract

A better grasp of the physical foundations of life is necessary before we can understand the processes occurring inside a living cell. In his physical theory of the cell, American physiologist Gilbert Ling introduced an important notion of the resting state of the cell. He describes this state as an independent stable thermodynamic state of a living substance in which it has stored all the energy it needs to perform all kinds of biological work. This state is characterized by lower entropy of the system than in an active state. The main contribution to this reduction in entropy is made by the cellular water (the dominant component with a concentration of 14 M) which remains in a bound quasi-crystallized state in a resting cell. When the cell becomes active the water gets desorbed and the system’s entropy goes up sharply while the free energy of the system decreases as it is used up for biological work. However, Ling’s approach is primarily qualitative in terms of thermodynamics and it needs to be characterized more specifically. To this end, we propose a new thermodynamic approach to studying Ling’s model of the living cell (Ling’s cell), the centrepiece off which is the non-ergodicity property which has recently been proved for a wide range of systems in statistical mechanics (Prokhorenko, 2009). In many ways this new thermodynamics overlaps with the standard quasi-stationary thermodynamics and is therefore compatible with the principles of the Ling cell, however a number of new specific results take into account the existence of several non-trivial motion integrals communicating with each other, whose existence follows from the nonergodicity of the system (Ling’s cell). These results allowed us to develop general thermodynamic approaches to explaining some of the well-known physiological phenomena, which can be used for further physical analysis of these phenomena using specific physical models.

Full text: http://vladimirmatveev.ru
 
Last edited:
Physics news on Phys.org


Vladimir Matveev said:
Dear Colleagues,

I would like to submit to your court the article in which we attempt a physical analysis of living matter. Biology is a very difficult field for physics as a result errors are very likely. We would appreciate guidance on possible errors.

"Structured Water" (which seems to be the main central theme) has been proposed many times to account for cellular dynamics- Ling's papers and ideas are featured prominently in Pollack's "Cells, Gels, and the Engines of Life".

Unfortunately, there is no evidence for structured water.

This does not discount the useful themes of non-ergodicity and the glass transition in describing cellular dynamics. Paul Janmey, in particular, has done some nice work along these lines.
 


Andy Resnick said:
"Structured Water" (which seems to be the main central theme) has been proposed many times to account for cellular dynamics- Ling's papers and ideas are featured prominently in Pollack's "Cells, Gels, and the Engines of Life".

Unfortunately, there is no evidence for structured water.

This does not discount the useful themes of non-ergodicity and the glass transition in describing cellular dynamics. Paul Janmey, in particular, has done some nice work along these lines.
Several strong evidences for existence of structured water you may find in the Pollack's presentation:
 
Last edited by a moderator:
The rope is tied into the person (the load of 200 pounds) and the rope goes up from the person to a fixed pulley and back down to his hands. He hauls the rope to suspend himself in the air. What is the mechanical advantage of the system? The person will indeed only have to lift half of his body weight (roughly 100 pounds) because he now lessened the load by that same amount. This APPEARS to be a 2:1 because he can hold himself with half the force, but my question is: is that mechanical...
Hello everyone, Consider the problem in which a car is told to travel at 30 km/h for L kilometers and then at 60 km/h for another L kilometers. Next, you are asked to determine the average speed. My question is: although we know that the average speed in this case is the harmonic mean of the two speeds, is it also possible to state that the average speed over this 2L-kilometer stretch can be obtained as a weighted average of the two speeds? Best regards, DaTario
Some physics textbook writer told me that Newton's first law applies only on bodies that feel no interactions at all. He said that if a body is on rest or moves in constant velocity, there is no external force acting on it. But I have heard another form of the law that says the net force acting on a body must be zero. This means there is interactions involved after all. So which one is correct?
Back
Top