If you also assume that the geometry of space-time is asymptotically flat at infinity, you can determine the total mass.
I've already presented the basic formula for this in another thread (I think it's several other threads by now). This formula can be found in Wald's general relativity (where I got it).
https://www.physicsforums.com/showthread.php?t=30020&page=7&pp=15
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M = 2 \int_{\Sigma} (T_{ab} - \frac{1}{2} T g_{ab}) n^a \xi^b dV<br />
Here Tab is the stress-energy tensor, gab is the metric tensor, na is the unit future normal to , and is the Killing vector representing the time translation symmetry of the static system. T is the trace of Tab.
Note that Pete's answer is not correct, there is more to determining the mass of a body than integrating the energy density.
To compute T_ab, assuming it's a perfect fluid, you'll need both the density (which will set T_00), and the pressure. If you assume a real fluid, you'll need an "equation of state" - the density of the fluid vs. it's pressure.