The discussion centers around calculating the number of ways to form a 3-digit number from the set {0,1,2,3,4,5} without repetition. There is a debate on whether numbers with leading zeros, such as 012, should be considered valid. If leading zeros are allowed, the total combinations amount to 120, calculated as 6 choices for the first digit, 5 for the second, and 4 for the third. However, if leading zeros are not allowed, the first digit can only be chosen from 1 to 5, resulting in 100 valid combinations when calculated as 5 choices for the first digit, 5 for the second, and 4 for the third. The key takeaway is that the interpretation of leading zeros significantly affects the total count of valid 3-digit numbers.