Be careful!
The total differential for a function of two variables is
df = \left( \frac{\partial f}{\partial x} \right )_y dx<br />
+ \left( \frac{\partial f}{\partial y} \right )_x dy
Therefore, the derivative you want is
\frac{df}{dx} = \left( \frac{\partial f}{\partial x} \right )_y<br />
+ \left( \frac{\partial f}{\partial y} \right )_x \frac{dy}{dx}
For the function you have given,
\frac{df}{dx} = \exp (x+y) + \exp (x+y) \frac{dy}{dx}
So, if you hold y constant, the second term on the right is zero and the
total derivative reduces to the partial derivative wrt x; however,
if you wish to know how f varies along a specified
path in the xy-plane, y=f(x),
then you must take the second term into account. If you wish a concrete
example, just read any text on chemical thermodynamics.