When the index set I is empty, the intersection of the collection of sets {A_i} is equal to the universal set S, as it is vacuously true that any element x in S belongs to all A_i. This conclusion is supported by the proof that if I is empty, then no element can exist in the union of the A_i, leading to a contradiction if one assumes otherwise. DeMorgan's Laws further validate that the intersection of the A_i equals S when I is empty. Discussions also touch on the implications of defining intersections in set theory, particularly in relation to the comprehension axiom and potential paradoxes. The conversation highlights the nuances of set definitions within different axiomatic frameworks, including ZF and ZFC.