Iron signifies the end of nuclear fusion in stars, marking their impending death. As iron accumulates in the core, it cannot undergo further fusion without an energy input, leading to a lack of pressure to counteract gravitational collapse. This collapse creates a dense core that triggers a supernova when the outer layers fall inward and release massive energy. The idea that iron is "poison" to a star reflects its role as a signal of exhaustion rather than a direct cause of explosion. Understanding the binding energy concept clarifies why iron's formation leads to a star's demise.