Cramer's rule will not fail in a linear system of equations if there is a unique solution, as the determinant of the coefficient matrix cannot be zero in that case. However, if the system has infinitely many solutions or no solutions, Cramer's rule can yield zero determinants for both the numerator and denominator. This does not indicate a failure of the rule itself but rather reflects the nature of the system being analyzed. Alternative methods, such as elimination or substitution, are often more effective for systems lacking unique solutions. Ultimately, Cramer's rule serves more as a theoretical tool rather than a practical solution method.