The Binomial Theorem is primarily applicable to natural number powers, but it can be extended to all real numbers through infinite series. This extension allows for fractional powers, such as 1/2, to be expressed as a sum of an infinite number of terms. The Gamma function plays a crucial role in this extension by broadening the factorial's domain from integers to positive real numbers. Consequently, any expansion involving irrational numbers necessitates an infinite series approach. Understanding these concepts enhances the application of the Binomial Theorem beyond its traditional limits.