Multiple simultaneous sample observations on a Microscope device?

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Discussion Overview

The discussion revolves around the feasibility of designing a microscope capable of observing multiple sample slides simultaneously, either through optical or electron microscopy. Participants explore the potential construction of a circular disc holding multiple slides and the implications for sample comparison in various applications.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested

Main Points Raised

  • Prashant S Akerkar proposes a design for a microscope that can hold 5-10 sample slides on a rotating circular disc, allowing simultaneous observation of multiple samples.
  • Another participant questions the application of such a design, asking if the intention is to superpose multiple optical images.
  • Prashant clarifies that the goal is to compare logically grouped samples, such as blood or urine, at the same time, regardless of whether they are grouped logically.
  • One participant mentions existing robotic microscope setups that automate slide loading for high throughput screening, suggesting that such systems may fulfill the requirements for rapid sample observation.
  • Prashant acknowledges the robotic slide loading system as a suitable solution, noting its potential for customization for different types of microscopes.
  • A later reply discusses automated CBC machines that process numerous samples quickly, indicating that similar technology exists for analyzing multiple samples efficiently.

Areas of Agreement / Disagreement

Participants express varying views on the practicality and application of the proposed microscope design. While some acknowledge existing technologies that automate sample processing, there is no consensus on the feasibility of the specific multi-slide observation concept.

Contextual Notes

Limitations include the lack of detailed specifications for the proposed microscope design and the dependence on the definitions of "simultaneous observation." The discussion does not resolve the technical challenges associated with achieving simultaneous imaging of multiple samples.

Who May Find This Useful

This discussion may be of interest to researchers in microscopy, medical diagnostics, and automation in laboratory settings, particularly those exploring innovative approaches to sample analysis.

akerkarprashant
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TL;DR
Multiple samples observations on a Microscope device.
Is it possible to design & construct a Microscope (optical or Electron) which can take multiple slides samples instead of a single sample slide at a time?.

Possible construction of the Sample Slides target is a circular disc holding say 5-10 sample slides. The Circular disc can be rotated holding the 5-10 sample slides. Light or Electrons evenly focussed on all the sample slides.

I.e. Different chambers for samples been observed with the Light or Electrons focussed on all the sample slides at a single time to produce multiple images of the respective slides.

Thanks & Regards,
Prashant S Akerkar
 

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Probably. What is the application? Are you wanting to superpose the multiple optical images for some reason?
 
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Thanks.

My intention was to view multiple sample slides at a single time which could be same logically grouped blood, urine, stool, semen, sputum etc. Useful for comparison of samples at a single time i.e. say blood.

Even if the samples are not logically grouped, one can view different samples images at a single time. Place all the 5-10 sample slides in the circular tray which can be rotated 360°.

Thanks & Regards,
Prashant S Akerkar
 
Thanks.

I feel the automated Microscope Robotic slide loading system which you described fulfills the requirements.

The product can be customised to suit different microscopes viz optical, electron etc.

Thanks & Regards,
Prashant S Akerkar
 
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There are automated CBC machines that read sample after sample. One I saw running -- by Bekman(?) Inc. -- ran 200+ samples per hour. CBC involves enumerating cell types in a blood sample. So this operation involves looking at and then and categorizing lots of cells in a single sample.

If you are doing medical research you probably can get "time" on machines like this through charitable use options.
 
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