Multiple simultaneous sample observations on a Microscope device?

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SUMMARY

The discussion centers on the feasibility of designing a microscope capable of simultaneously observing multiple sample slides using a circular disc mechanism that can hold 5-10 slides. This innovative design aims to facilitate the comparison of various samples, such as blood and urine, by focusing light or electrons on all slides at once. Robotic microscope systems, such as those offered by Prior Scientific, can automate slide loading for high-throughput screening, effectively meeting the requirements for rapid sample analysis. Automated CBC machines, like those from Beckman Coulter, exemplify existing technology that processes over 200 samples per hour, showcasing the potential for efficiency in medical research.

PREREQUISITES
  • Understanding of optical and electron microscopy principles
  • Familiarity with robotic automation in laboratory settings
  • Knowledge of high-throughput screening techniques
  • Basic concepts of complete blood count (CBC) analysis
NEXT STEPS
  • Research the design and functionality of robotic slide loading systems for microscopes
  • Explore the specifications and capabilities of automated CBC machines
  • Investigate the principles of light and electron beam focusing in microscopy
  • Learn about the integration of circular disc mechanisms in laboratory equipment
USEFUL FOR

Microscopists, laboratory technicians, medical researchers, and anyone involved in high-throughput sample analysis will benefit from this discussion.

akerkarprashant
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TL;DR
Multiple samples observations on a Microscope device.
Is it possible to design & construct a Microscope (optical or Electron) which can take multiple slides samples instead of a single sample slide at a time?.

Possible construction of the Sample Slides target is a circular disc holding say 5-10 sample slides. The Circular disc can be rotated holding the 5-10 sample slides. Light or Electrons evenly focussed on all the sample slides.

I.e. Different chambers for samples been observed with the Light or Electrons focussed on all the sample slides at a single time to produce multiple images of the respective slides.

Thanks & Regards,
Prashant S Akerkar
 

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Probably. What is the application? Are you wanting to superpose the multiple optical images for some reason?
 
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Thanks.

My intention was to view multiple sample slides at a single time which could be same logically grouped blood, urine, stool, semen, sputum etc. Useful for comparison of samples at a single time i.e. say blood.

Even if the samples are not logically grouped, one can view different samples images at a single time. Place all the 5-10 sample slides in the circular tray which can be rotated 360°.

Thanks & Regards,
Prashant S Akerkar
 
Thanks.

I feel the automated Microscope Robotic slide loading system which you described fulfills the requirements.

The product can be customised to suit different microscopes viz optical, electron etc.

Thanks & Regards,
Prashant S Akerkar
 
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There are automated CBC machines that read sample after sample. One I saw running -- by Bekman(?) Inc. -- ran 200+ samples per hour. CBC involves enumerating cell types in a blood sample. So this operation involves looking at and then and categorizing lots of cells in a single sample.

If you are doing medical research you probably can get "time" on machines like this through charitable use options.
 
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