I had a question as to why WBC cant attack Naegleria fowleri when it attacks the brain ?
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Who says they can't? its a common organism that rarely causes disease but quite a lot of people have antibodies to the organism suggesting exposure is quite common. The brain is what's referred to as immune privileged, because a sever inflammatory response could cause more damage than whatever caused it it is to some extent isolated from the rest of the bodies systems and has its own specialist immune cells. This is a fairly large mobile amoeba which is attracted to neuro-chemicals, it enters the body through the nose and tracks into the brain. Its no great surprise that phagocytes have difficulty containing it, this happens in a lot of infections but we do mount an antibody response that appears to control the amoeba. There may be all sorts of reasons why this antibody response fails in a small number of people, a guess might be the transit time from nose to brain but there are all sorts of possibilities. Apparently around 80% of cases are in males and around 66% in children but this might simply indicate risky behaviour. Its difficult to diagnose and despite having effective drugs few victims survive.
Whether safely is the right word is debatable or even if the antibodies act in the brain or prevent the organism reaching the brain but for antibodies to develop it suggests that our immune system will have been exposed to the organism for some time and so the money must be on the infection being present but asymptomatic. Its always difficult to get good information about rare conditions.
This seems to give a good overview.
The organism normally feeds on bacteria so its logical to assume that they will engage in phagocytosis it is also suggested that it produces two proteases -- enzymes that dissolve protein, so they liquefy the brain.
Some light reading
which has a number of other links to follow up
and some drugs to look up;
Amphotericin B was the standard of treatment. Lately this has been combined with Miltefosine and along with high doses of steroids has resulted in two patient recoveries.
thank you so much !!!! It was extremely detailed and i got all that i wanted !