Firstly,they are all intertwind and different parts of the same underlying symmetry of nature.But I think I can regard the third law as more profound than the first two laws.
Newton’s 3rd law is valid in any frame, inertial and non inertial, it is independent of the concept of inertia.
Let me justify that truly, 3rd law is independent of 1st and 2nd laws.
My plan to check whether 3rd law is independent of 1st law and 2nd law is to see
i) When 3rd law is valid, in which frame we are.
ii) When it is not valid, in which frame we are.
i) When 3rd law is valid we are in an inertial frame; but we may also be in a non-inertial frame! Since 3rd law deals with only interaction forces (as per its statement) ['interaction force' only means one can find who applies the force on whom and how is himself affected] even in an accelerating frame, these forces satisfy 3rd law. After we know about frames and forces, we can identify them to be real forces.
ii) When it is not valid, we cannot conclusively say that we are in a non-inertial frame. There are cases in electrodynamics where in an inertial frame non-relativistic charge particles do not satisfy 3rd law in spite of their real interaction. You may choose to read Griffiths, 8.2: Momentum.
Note, we need not use 2nd law for calculating force magnitudes, 3rd law gives them ready- made to us.
Another essential concept I wish to show is that force is the result of an interaction between two systems is made explicit by the 3rd law.This affects both the bodies involved.And one cannot simply apply F=ma on an isolated body even in an inertial frame.So,it is an essential concept in making sense to the other two laws...
As DH said, "isolated" bodies cannot be conceived in reality" ,"3rd law fails in some cases", 2nd law also does not describe the reality in its full.Since,in general,force is a function of time,there are other higher order derivatives that are needed to describe the motion appropriately.
Generally,we are interested to see if the law applies to desired degree of accuracy.