Organic: lanosterol Biosynthetic Cyclization

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The discussion focuses on the biosynthetic cyclization of oxidosqualene, which is catalyzed by oxidosqualene cyclase (OSC) to produce lanosterol. The reaction begins with a protonation step, and participants are asked to indicate the electron flow following this step using curved arrows. It is suggested to identify "hot spots" in the provided diagram to accurately depict the electron movement. Additionally, counting the hydrogens on each carbon may help in understanding the reaction mechanism. The complexity of the reaction is acknowledged, indicating a challenging nature of the topic.
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This is a tough one!

Shown is the biosynthetic cyclization of oxidosqualene catalyzed by oxidosqualene cyclase (OSC) leading to lanosterol as the final product.

The reaction starts with a protononation step as shown. Indicate the flow of electrons after the initial protonation step leading to the product given.

Indicate the flow of electrons by starting your curved arrow at a bond or unshared electron pair.
In this question, the endpoint of your curved arrow will be an atom.
You should be able to find appropriate hot spots in the drawing.

[PLAIN]http://owl.cengage.com/mediaarchives/OrgChemJuly2009/Image/B7.28b.gif
 
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whatlifeforme said:
This is a tough one!

Shown is the biosynthetic cyclization of oxidosqualene catalyzed by oxidosqualene cyclase (OSC) leading to lanosterol as the final product.

The reaction starts with a protononation step as shown. Indicate the flow of electrons after the initial protonation step leading to the product given.

Indicate the flow of electrons by starting your curved arrow at a bond or unshared electron pair.
In this question, the endpoint of your curved arrow will be an atom.
You should be able to find appropriate hot spots in the drawing.

[PLAIN]http://owl.cengage.com/mediaarchives/OrgChemJuly2009/Image/B7.28b.gif[/QUOTE]

One way to start might be to count the hydrogens on each carbon?
 
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