A vacuum is defined as a region of space devoid of matter, often described as having negative pressure. It does not consist of any medium, but rather represents a space that can potentially be occupied. The discussion highlights the difference between a vacuum in the universe and the concept of what the universe is expanding into, emphasizing that the universe is not expanding into anything. Intergalactic vacuum contains minimal particles, such as primordial gas and photons, and exhibits properties like dielectric permeability and magnetic permittivity. The concept of vacuum energy and virtual particles is noted to be relevant primarily in strong Coulomb fields rather than in intergalactic space.