To determine if a sequence is monotonic using differentiation, one must analyze the function's derivative to see if it remains positive (increasing) or negative (decreasing) across its domain. For a sequence to be eventually monotonic, it must satisfy monotonicity conditions beyond a certain index N, which can be established through trial and error or by finding a point where the function stabilizes. Monotonic functions are either consistently increasing or decreasing, and this can be verified by comparing function values at specific points. However, not all functions can be proven to be eventually monotonic, as some, like sin(x), continue to fluctuate indefinitely. Understanding these concepts is crucial for effectively analyzing sequences and their behavior.