Quaternary ammonium compound solubility

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The discussion centers on the solubility of a quaternary ammonium compound with a specific composition of 60-80% quaternary ammonium, 10-20% isopropanol, and 1-10% water. The key question is whether isopropanol is the optimal organic solvent for this compound or if a combination of isopropanol and water would enhance solubility. It is noted that quaternary compounds are ionic, which may necessitate the inclusion of water to neutralize the counterion. The solubility can vary based on the type of counterion used; for instance, larger quaternary ammonium compounds paired with non-coordinating counterions like tetraphenylboron or hexaphenylphosphate may exhibit reduced solubility in water. The discussion highlights the importance of considering both the solvent choice and the specific characteristics of the quaternary ammonium compound when determining the best solvent system.
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Hello all,

I have a question about the solubility of a certain compound. The compound in question is a quaternary ammonium compound 60-80% concentration, 10-20% isopropanol, and 1-10% water.

Is isopropanol the best organic solvent for this compound or would a combination of isopropanol and water be a better solvent? There is also a possibility that another organic solvent is more suitable for the quaternary ammonium compound.

Thank you in advance.
 
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Quaternary compounds are ionic, so water can be necessary to "neutralize" counteranion.
 
It depends on the counterion and the quat. A large greasy quat coupled with a non-coordinating counterion like tetraphenylboron or hexaphenylphosphate might make the quat less soluble in water.
 
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