Questions bout the Chloride Shift in R.B.cell

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The discussion centers on the chloride shift in red blood cells, specifically the roles of bicarbonate (HCO3-) and chloride ions (Cl-). After carbon dioxide dissociates into H+ and HCO3-, HCO3- exits the cell to prevent cytosolic alkalosis and maintain pH balance, while Cl- enters to maintain osmolarity. The need for Cl- is emphasized despite H+ binding to hemoglobin, as the chloride shift helps regulate ion concentrations within the cell. The conversation highlights the importance of these mechanisms in maintaining homeostasis in red blood cells. Understanding the chloride shift is crucial for grasping how red blood cells manage gas exchange and pH levels.
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Hi, i have a question bout the chloride shift that occurs in the red blood cell. After the carbon dioxide has dissociated into the Red Blood Cell's plasma and became H+ and HCO3- i would like to know why must the HCO3- must go out and combine with the Sodium ions and since the H+ ions have combined with Hemoglobin, Hb. Why is Cl- still needed and shifted into the Red Blood Cell? Doesn't H.Hb is already neutralized?

Sorry if you think this is a very easy question, but my book just told me there is a chloride shift, there is no explanation given on the mechanism. Thanks.
 
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A wild guess:
Maybe there's not much space for all that HCO3- in the RBC, its m.wt. being 61 and for Cl- it is 35 ?

A better guess I think would be the altered pH of the RBC cytosol due to HCO3- accumulating in it causes it to become more basic?
Maybe the HCO3- may try to displace the H+ from H.Hb hence it has to be transported out?

Cl- is anyway needed for the maintenance of the osmolarity
 
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