The famous relationship is properly ##E=\gamma mc^2##, where the gamma comes from relativity.
It is an identity - mass is another form of energy.
The Universe has other rules - you cannot freely convert one form of energy into another.
i.e. kinetic energy does not spontaneously turn into gravitational potential energy - you also have to direct the momentum upwards.
As well as conservation of energy, you have to obey other conservation laws.
One of them is a conservation of charge.
The effect of charge is that you can only create charged particles in oppositely charged pairs.