What you're dealing with isn't an equation; it's an inequality, and they're trickier to work with than equations, since you have in take into account the the two factors (or three, if you factor the x2 - 16 expression) can be zero or can be negative.
It's easy to determine where (x + 3)(x2 - 16) is equal to zero, but takes a little more work to find where it is less than zero. For the above to be negative, it must be that either
a) x + 3 < 0 and x2 - 16 > 0, or that
b) x + 3 > 0 and x2 - 16 < 0
What do you get if you follow this reasoning for the two pairs of inequalities?
You can also approach it using the three linear (i.e., first degree in x) factors. To get a negative product, one factor has to be negative and the other two have to be positive. Taking that approach, you'll have three sets of three inequalities, but it might be that one of the sets has no solution.
Hope that helps.
Mark