There is no difference in the basic principle regardless of what part of the atom it comes from, and I believe you know that already. Einstein's formula still applies and is calculated exactly the same way.free_mind said:Einstein's formula it's all about different kinds of energy. Sure, there are some radioactive decay processes following nuclear fission, and, if so inclined, one can view the decay of a neutron decaying into a slightly lighter proton as a transformation of rest energy into other energy forms. But these additional processes contribute a mere 10 per cent of the total energy set free in nuclear fission. The main contribution is due to binding energy being converted to other forms of energy - a consequence not of Einstein's formula, but of the fact that nuclear forces are comparatively strong, and that certain lighter nuclei are much more strongly bound than certain more massive nuclei.
So my question is, what are you really asking here in this forum? Are you trying to get the answer to a question (somehow I am beginning to doubt this) or are you trying to make a specific statement? If you are trying to make a statement, perhaps you could move forward to that.