Careful said:
Are you hoping that ZPE is something *physical* ?
ZPE is physical whenever it couples to gravity; and whenever one may compare the total energy between two configurations with different net values of ZPE. In other words, ZPE is almost always physical.
In particular, the cosmological constant - which is physical because it makes the expansion of the Universe accelerate - has contributions from ZPEs from all known fields in Nature. The expected largeness of these terms - so much larger than the observed cosmological constant - is called the cosmological constant problem.
But there are also "non-problematic" examples of the ZPE. ZPE of the electromagnetic field (coming from all the allowed standing wave modes) between two metallic plates depends on the plates' distance. That's why the gradient of this total energy will be demonstrated as the Casimir force - an effect that's been experimentally verified to agree with the predictions fully based on ZPEs.
After all, the negative binding energy of the Hydrogen atom, any other atom, or any other quantum physical system is nothing else than a generalization of ZPE for different-than-quadratic potentials. All these things are totally physical and observable.
One must be very careful about ZPEs in string theory because they're the simplest players to demonstrate many effects.
For example, the very critical dimension D=26 of the bosonic string and D=10 of the superstring may be derived from the ZPEs. For example, in the bosonic case, there are D-2 transverse bosonic oscillators of a bosonic string. Each of them gives a hbar.omega/2 ZPE. However, the frequencies depend on the wave number along the string and one must sum over them. So the total ZPE of these vibrations is proportional to
(D-2) x sum (n/2)
The sum goes over n from 1 to infinity.
Here, D-2 comes from the number of transverse directions, n comes from the wave number (in frequency), and 1/2 is from hf/2. The first excited state must be massless because we only have (D-2) states at this level - from D-2 transverse oscillators - instead of (D-1) that would be needed for the little group of a massive particle. That means that
(D-2) x sum (n/2) + 1 = 0.
However, the sum of positive integers is -1/12, so we have
(D-2) x (-1/24) = -1,
D-2 = 24,
D = 26,
the right critical dimension. This calculation is not just a funny dirty trick, it's the actual conformally correct calculation that may be phrased in a more formal regulated framework but the essence of the calculation will be the calculation above, anyway.
There exist equivalent ZPE-based calculations of the critical dimension. In the covariant formalism, the bc-ghosts actually have the central charge c=-26, requiring D=26 bosons to cancel the conformal anomaly on the world sheet. The c=-26 result may also be reduced to some kinds of ZPE terms.
In supersymmetric theories, ZPEs typically tend to cancel.
At any rate, string theory makes these features of quantum theory more important, not less important or more disputable. Any hope that string theory would "undo" some of the key insights of the quantum revolution or relativistic revolution is totally misguided. String theory is another step in the progress towards more accurate and more complete physical theories - perhaps the last step. It is surely not a step to return physics to the 19th, 18th, or 17th century. ;-)