S Plus is commonly used in academic settings but can feel cumbersome for some users. Many participants recommend transitioning to R after completing their courses due to its broader user base and similar syntax to S Plus. R is favored in the statistics community, while SAS is preferred in biostatistics. Users also discuss the merits of Matlab for numerical computations, noting that it excels in engineering applications. Ultimately, the choice of software depends on specific fields and personal proficiency, with free and open-source software (FOSS) options often being sufficient for most statistical needs.