Take for example a human being inside a wooden crate. One can not see, taste, touch, smell or hear the human inside the crate, or whatever it is being tested against. We know roughly the outer dimensions of the crate giving an upper limit to the size of the human being within plus or minus a foot in every dimension. One can also get a rough mass of the object plus or minus a kilogram. The question is then how would one go about testing to see if there is in fact a human being inside? What if two crates were presented, both having the same dimensions and masses yet one has a human being and the other has lead, or an ape, in it how would one tell the difference? The idea hinges on similar limitations presented with measuring sub-atomic particles, without the minute scale. What kind indirect and direct observations in any form can be made to indicate human presence?