For biological systems, the sphere is just about the worst shape to use, since it places a severe limit on how big/how efficient the organism can be.
To see this in simplified form:
1. Let V stand for a volume, S for the associated surface
2. Let N stand for "needed nutrients (stuff) per unit volume", and let P stand for "amount of stuff able to permeate the surface, per unit surface area"
Thus, if a cell/organism is to survive, we evidently need the inequality:
P*S\geq{N}*V
or, rewritten:
\frac{V}{S}\leq\frac{N}{P}
For a spherical object with radius r, this indicates a maximal size given by:
r\leq\frac{3N}{P}
Rather than being spherical, then, many structures in the cell have extremely wrinkled surfaces (like the
mitochondria, Golgi apparatus, and so on), making them more efficient in the uptake process.
Note that for a BIOLOGICAL system, ensuring adequate access to nutrients is along with minimizing energy expenditure and gene propagation the most important issues. None of these issues are really relevant for a non-biological system. This explains that common "strategies" for non-biological systems might not be optimal for the biological systems.