Can Organisms be Genetically Engineered to Not Build Drug Tolerance?

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SUMMARY

The discussion centers on the feasibility of genetically engineering organisms to prevent drug tolerance, a natural physiological response. Participants reference Paracelsus' principle that "the dose is the poison," highlighting the complexity of drug interactions and tolerance development. The conversation emphasizes that speculative thought experiments are not permitted, focusing instead on established scientific principles regarding drug tolerance mechanisms. Ultimately, the thread concludes without definitive answers, reinforcing the need for grounded scientific inquiry.

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  • Understanding of pharmacology and drug tolerance mechanisms
  • Familiarity with genetic engineering techniques
  • Knowledge of holistic medicine principles
  • Awareness of historical figures in medicine, such as Paracelsus
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  • Research genetic engineering methods for modifying drug response in organisms
  • Explore pharmacological studies on drug tolerance and resistance
  • Investigate the implications of holistic medicine on drug efficacy
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Researchers in pharmacology, genetic engineers, medical professionals, and anyone interested in the intersection of genetics and drug efficacy.

GladScientist
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Hi everyone. In a thought experiment that I like to frequent, an important question arises. Is tolerance (the body's natural resistance to the effects of drugs) a technique that we've evolved to not grow too content with our current situation? Or, do the laws of chemistry determine that tolerance must exist?

Is it or is it not possible to potentially genetically engineer an organism that does not build tolerance to drugs?
 
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You might want to look up Paracelsus, "The dose is the poison," or words to that effect. Holistic medicine. Cumulative poisons/effects.
 
GladScientist said:
Is it or is it not possible to potentially genetically engineer an organism that does not build tolerance to drugs?
Your questions cannot be answered. We don't allow "thought experiments" here, we stick to mainstream known science. If you have a specific question about how the body builds up tolerance, that would be allowable. This thread is closed.
 

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