The discussion centers on identifying the top five pandemics that remain uncured today. Participants clarify the distinction between pandemics and epidemics, noting that while AIDS is a significant issue in Africa, it is classified as an epidemic rather than a pandemic. The conversation shifts to focus on the most deadly incurable infectious diseases, emphasizing that these are primarily viral diseases due to the effectiveness of antibiotics against bacterial infections. Key examples mentioned include AIDS, influenza, and hepatitis B, which are highlighted for their long-term impact on hosts, allowing for widespread transmission. The discussion also touches on Ebola, which, despite its high mortality rate, is less concerning in terms of epidemiological spread because it kills its host quickly. Overall, the emphasis is on the ongoing challenges posed by these viral diseases in public health.