Every field, every particle, every bit of energy, all their complicated interactions and systems, molecules, things, everything in the universe has causal interactions with something else. Understanding this, the nature of things, all of it, is what knowledge and science and experiment is for. It is crucial to understand the nature of everything, and hence, if space-time is another thing that could have a nature, its something we need to investigate and understand.
To have within our equations a concept, "space-time" whose referent "might be" one of those very things about which its nature and effects and possible applications would be crucial to know VERSUS simply a background parameter for relating and describing the real things in the universe, is incredibly important distinction relevant to our knowledge.
The very question of whether something is one of the things we are studying and gaining knowledge about versus simply one of our tools to help us understand all other things (the real things) is not trivial nor unscientific. It is fundamental to the exercise and understanding of science.
If it were true that space-time in fact was something, then it would be possible to design an experiment which could show in some way the nature of space-time and its interaction with other things, for example could it be balled up and stored in a smaller space, could it be converted into energy or matter or anything else, can it be used to cause something or interact with other things. The number of possible experiments and indeed applications and technologies is endless... certainly that is if it IS a thing in itself.