What Defines Synthetic Bacteria and Their Natural Identities?

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Synthetic bacteria have been developed, with the M. mycoides synthetic genome being a notable example. This genome is termed "synthetic" because it was created using DNA synthesis machines and lab chemistry, closely resembling its natural counterpart but with added "watermark" DNA for identification. The discussion raises questions about the definition of "synthetic" in this context, particularly regarding whether these bacteria fully replicate the identities and observable behaviors of their natural counterparts. There is also interest in the concept of a minimal genome, where researchers aim to delete non-essential DNA while maintaining the bacteria's ability to self-replicate and grow. The focus is on understanding cooperative activities in bacterial reproduction and replication.
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Synthetic bacteria have been created, which isn't new anymore,
http://www.nytimes.com/2010/05/21/science/21cell.html

But I don't know how to correctly define "synthetic" in this work. Are those synthetic bacteria possessing complete identities as those in nature ? Did they try out the bacteria's most observable behaviors ? I am interested in cooperative activities in bacteria reproduction and replication.
 
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The M. mycoides synthetic genome is considered "synthetic" because the DNA used began in a DNA synthesis machine, using lab chemistry techniques to produce it. The actual genome was pretty much a replica of the natural one, with some "watermark" DNA added to uniquely identify it by the creators (like the watermark on money, or the signature on a work of art).

If i remember correctly they may have deleted some DNA that they considered unnecessary, but it was largely just like copy-paste.

The same folks, JCVI, have also been interested for a while in a minimal genome, and had talked of deleting as much DNA as possible while still retaining self-replication and growth of cells.
 
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