The energy efficiency of the human body for weight loss is estimated to be around 20%, meaning that climbing a 22.5m building while weighing 114 kg burns approximately 30 food calories per trip, not the initially calculated 6000 calories. This discrepancy arises because food calories are actually kilocalories, leading to confusion in energy expenditure calculations. Climbing stairs is deemed tedious, and the discussion suggests that engaging in enjoyable activities is more sustainable for long-term weight loss. Proper nutrition is also emphasized as essential for effective weight management. Overall, the conversation highlights the challenges of using physical activity alone for significant weight loss.