What is the length of Chromatosomal DNA?

  • #1
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I see various sources:
1. Karp- Cell biology
2. some papers
3. Michael M. Cox - Molecular Biology
mention different values for the length of DNA associated with the nucleosomes (Octamer and H1); 168bp and 200bp. I'm a lost. Is there any paper that has settled this confusion once and for all?
 

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  • #2
Ygggdrasil
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Canonically, the nucleosome core particle wraps 147 bp. Varying studies come up with different numbers protected by the linker histone (H1), for example, see paragraph 6 of http://www.nature.com/nsmb/journal/v5/n12/full/nsb1298_1025.html. A very recent structure of the ncp + linker histone used 197 bp of DNA, so ~200 bp may be the more generally accepted number now: http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30268-X I do know that there has been controversy over how H1 engages the ncp, and I'm not sure whether the field sees the Mol Cell paper as a definitive answer or if other groups have data in the works to support other structural models.http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30268-X
 
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