What is the origin of plasmids?

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Discussion Overview

The discussion revolves around the origin of plasmids, exploring their characteristics, replication, and potential evolutionary pathways. Participants delve into the relationship between plasmids and other biological entities, such as viruses and mitochondria, while questioning the definitions of life and the evolutionary implications of these relationships.

Discussion Character

  • Exploratory
  • Debate/contested
  • Conceptual clarification

Main Points Raised

  • Some participants propose that plasmids, similar to mitochondria, possess their own genetic material and can replicate independently within a host.
  • There is a suggestion that plasmids are not derived from the bacterial chromosome but rather replicate autonomously, raising questions about their origins.
  • One participant questions how the first plasmid entered the first bacterium, speculating whether it could have originated from a virus or another prokaryotic cell.
  • A later reply introduces the idea that the definition of life may need to be reconsidered in light of discoveries related to mega-viruses and their characteristics.
  • Another participant draws parallels between the origins of life and modern symbiotic relationships, such as those seen in lichens, suggesting that components may evolve towards a state similar to plasmids.

Areas of Agreement / Disagreement

Participants express differing views on the origins and definitions related to plasmids and life, with no consensus reached on these topics. The discussion remains unresolved with multiple competing hypotheses presented.

Contextual Notes

Participants reference various historical and contemporary sources, indicating that some information may be outdated or incomplete. There are unresolved questions regarding the evolutionary pathways and definitions discussed.

jaumzaum
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As I understand it, plasmids, like mitochondria, have their own genetic material and are capable of self-replication.

According to Wikipedia: Plasmids are considered replicons, units of DNA capable of replicating autonomously within a suitable host. However, like viruses, they are not classified as life. Plasmids are transmitted from one bacterium to another through conjugation. Unlike viruses, plasmids are "naked" DNA. However, some classes of plasmids encode the conjugative "sex" pilus necessary for their own transfer.

My understanding of that is that a bacteria gets their plasmids not because of the replication of their circular chromosome, nor because that chromosome have genes to code for the plasmid (I don't really know if that's possible), but because of the self-replication of their own plasmids.

So, my question is how the first plasmid got into the first bacteria, if they are not in their chromosomes? Were they a virus other prokaryotic cell that had circular DNA, and got phagocytosed by that bacteria ?
 
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jaumzaum said:
As I understand it, plasmids, like mitochondria, have their own genetic material and are capable of self-replication.

According to Wikipedia: Plasmids are considered replicons, units of DNA capable of replicating autonomously within a suitable host. However, like viruses, they are not classified as life. Plasmids are transmitted from one bacterium to another through conjugation. Unlike viruses, plasmids are "naked" DNA. However, some classes of plasmids encode the conjugative "sex" pilus necessary for their own transfer.

My understanding of that is that a bacteria gets their plasmids not because of the replication of their circular chromosome, nor because that chromosome have genes to code for the plasmid (I don't really know if that's possible), but because of the self-replication of their own plasmids.

So, my question is how the first plasmid got into the first bacteria, if they are not in their chromosomes? Were they a virus other prokaryotic cell that had circular DNA, and got phagocytosed by that bacteria ?
Originally from another prokaryote I would have thought as per the mitochondria
 
jaumzaum said:
As I understand it, plasmids, like mitochondria, have their own genetic material and are capable of self-replication.

According to Wikipedia: Plasmids are considered replicons, units of DNA capable of replicating autonomously within a suitable host. However, like viruses, they are not classified as life. Plasmids are transmitted from one bacterium to another through conjugation. Unlike viruses, plasmids are "naked" DNA. However, some classes of plasmids encode the conjugative "sex" pilus necessary for their own transfer.

My understanding of that is that a bacteria gets their plasmids not because of the replication of their circular chromosome, nor because that chromosome have genes to code for the plasmid (I don't really know if that's possible), but because of the self-replication of their own plasmids.

So, my question is how the first plasmid got into the first bacteria, if they are not in their chromosomes? Were they a virus other prokaryotic cell that had circular DNA, and got phagocytosed by that bacteria ?
A quick search has given me a few things but they are quite old.
One from Leeuwenhoek 1998
What have you found?
 
IMHO, the recent discovery of mega-viruses, including some with size and/or genetics bigger than small bacteria, suggests 'Life' definition needs to be loosened.

Is pollen alive ? Not without a female flower. So, akin to a virus or phage...
Spores ? Yes, as self contained...

Tricky.
Looks like the origins of 'life as we know it' were even more of a 'free for all' orgy than 'tis yet comfortable to admit.

Modern parallel may be 'lichen', which is, wiki-quote, 'a composite organism that emerges from algae or cyanobacteria living among the filaments (hyphae) of the fungi in a mutually beneficial symbiotic relationship.'

IIRC, recent research suggests many lichens have a third, previously unsuspected team-member, yeast. This is also a fungi, but has evolved a rather different life-style...

Whatever, IIRC, several lichens' components seem well along to losing their independence, discarding 'surplus' genetic function, perhaps evolving towards what far future might consider akin to 'plasmids'...
;-)
 

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