Gracy, what names you give to variables is not so important so long as you define them, are consistent in their use, and they convey some idea of what they are meant to represent. This just boils down to naming conventions for quantities. You can choose any variable names you want if you are so inclined, so long as you define them for your audience, usually by showing them on the circuit diagram.
It is typical to use ##V## for voltages, ##I## for currents, ##R## for resistances, and so on, and to give them subscripts or suffixes to distinguish them. Input or source voltages are often labelled ##V_i## or ##V_s## or ##V_o## (meaning "original" or initial value). What you want to take as an output voltage for whatever purposes you have at the time can be labelled any way you want, but common choices include ##V_{out}##, ##V_o## (Yes, it can be used for both input or output labels, just not both at the same time!). Some people prefer to use U instead of V for voltages. It's a cultural thing. It should not cause confusion because variables should ALWAYS be defined before they are used!
Sometimes you want to reference a voltage across a particular component and then you might find it convenient to use, for example ##V_{R1}## or ##V_{C3}## where R1 and R3 are labelled components in your circuit diagram.
It's up to
you to define your variables and labels for a given problem. If you are writing equations using variables then you should know what they represent beforehand because
you have defined them. If you want to call the potential across any component the "output" of your circuit, that's entirely up to you. There is no strict rule about where that component has to be located in the circuit diagram (although most prefer to read circuit diagrams from left to right, top to bottom, input towards output. It's just a convention, and
not a strict rule).
Above you presented a derivation for the voltage across a particular resistor in a voltage divider. You used variables R1, R2, Rtot, I, Vs and Vo. Each was clear in its use and intent, and you defined mathematically that Vo = I × R2 and correctly presented the finished expression. Yet now you are coming back to ask what the variables mean, and how to recognize the output? This doesn't make sense: You defined and used them yourself.
You can extend the voltage divider from two to any number of resistors and choose the potential across anyone of them to be your "output".