S&P 500 futures fell 6.6 points to 1,209.70 and Nasdaq 100 futures dropped 7.75 points to 1,725.25. Dow industrial futures lost 25 points.
"Due to this week's failures in the financial sector, banks, insurance firms, the fund industry, and non-regulated financial institutions will have to absorb further losses," said Tim Brunne, a strategist at UniCredit. "There is systemic pain in the financial world."
"The futures are down on disappointment the job couldn't get done privately, but this should end up being a positive," said Marc Pado, a strategist at Cantor Fitzgerald.
U.S. stocks climbed on Tuesday on speculation of an AIG rescue, which took away from an initial negative reaction to the Fed's move to keep interest rates at 2%. The Dow industrials rose 141 points, the Nasdaq Composite added 27 points and the S&P 500 rose 20 points.
AIG fell nearly 27% in pre-market trade.