diazona said:
What?! That doesn't make sense at all. Just because the equation deals with rest mass does not mean a derivation based on four-momentum or Lorentz transformations is invalid.
It is not a derivation question, it is a fundamental question. One that goes below the mathematics, and asks what is the fundamental nature of particle mass energy.
As the E in E=mc^2 can be photon energy, let me rephrase the question using the particle mass energy and the equivalent photon energy. Note experimentally 2 equivalent rest mass particles, the electron and the anti-electron (positron) can annihilate to produce two photons. I will reference this specific case (the answer to the question must be universally true so it must be true it this specific case also) with the condition that both electron and anti-electron are at rest at time of annihilation (even if not possible to physically do this experiment, the present theory allows us to consider this possibility).
As the two particles are of equal mass and as conservation of momentum requires the two resultant photons must be of equal energy and momentum and must head out in opposite directions (net momentum 0), the rest mass relationship is 2 m c^2 = 2 E_ph
Thus for, let's say the anti-electron (or electron) the single particle's mass is converted to a single photon where the relationship between the single particle's rest mass has the equivalent energy of a photon given by the relationship m c^2 = E_ph.
What is the physics that allows the mass energy form to be at rest and resist a change to velocity and what is the substantive physics difference (not the mathematical difference) of the anti-particle that interacts with the particle nature that causes the transform of the mass form of energy to the photon energy form and why does this energy form always and immediately accelerate to the velocity c and what is the source nature of the photon acceleration which unlike mass energy occurs without requiring any energy input and without any energy loss?
Once you have answered this fundamental question, which requires a deeper understanding of the source of nature (why nature is this way) not just a mathematical form that indicates how nature behaves, then one can answer the question of why the relationship E=mc^2 exists in the first place rather than how relationships are known to behave.
For example string theory attempts to give an underlying foundation (source of behavior) to the present theory, the SM, that models the behavior of particles.
Many/most believe the model of the behavior of the particle is a model of the particle itself.
Some, including some famous physicists do not. If you are interested, read Roger Penrose's book, The Road to Reality. It is both a mathematically informative and a philosophically informative.