Why do some cells grow back very slowly?

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Discussion Overview

The discussion revolves around the varying regenerative capabilities of different cell types, specifically why some tissues, like nerve and muscle tissue, grow back slowly or not at all, while others, such as epithelial cells in the skin, regenerate quickly. The conversation touches on evolutionary perspectives and the biological mechanisms behind tissue regeneration.

Discussion Character

  • Exploratory, Conceptual clarification, Debate/contested

Main Points Raised

  • One participant notes that nerve and muscle tissues do not regenerate well, while skin epithelial cells do, questioning the underlying reasons for this difference.
  • Another participant proposes an evolutionary perspective, suggesting that the ability to quickly regrow skin cells may have provided a reproductive advantage, while the ability to regenerate spinal column cells did not offer a similar benefit in certain scenarios.
  • A different viewpoint is introduced, arguing that the specialization of certain cells may hinder their ability to regenerate, comparing it to the difficulty of cloning an experienced individual versus starting anew.
  • A later reply mentions that olfactory neurons are continuously replaced throughout human life, indicating that not all nerve cells have the same regenerative capacity.

Areas of Agreement / Disagreement

Participants express multiple competing views regarding the reasons for differences in tissue regeneration, with no consensus reached on the primary factors influencing these processes.

Contextual Notes

Some claims depend on specific definitions of cell specialization and regeneration, and the discussion does not resolve the complexities of how different cell types respond to injury.

sameeralord
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Nerve and muscle tissue don't grow back much but epithelial cells in the skin grow very quickly. Why is that some tissues find it difficult to grow back and are replaced by fibrous scar tissue. Can't they do some mitosis and regrow? Thank you :smile:
 
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Evolution.

Blob A could grow back skin cells quickly after a minor scratch, lived to reproduce and spread the ability to all the little baby blobs.

Blob B had the ability to regrow spinal column cells, unfortunately the nerve damage was due to being bitten in half by big nasty blob C so the ability was no advantage.
 
mgb_phys said:
Evolution.

Blob A could grow back skin cells quickly after a minor scratch, lived to reproduce and spread the ability to all the little baby blobs.

Blob B had the ability to regrow spinal column cells, unfortunately the nerve damage was due to being bitten in half by big nasty blob C so the ability was no advantage.

Interesting but I have another opinion as well. May be because these cells are so specialized you can't directly reproduce them. Like a person with a lot of experience you can't just clone him but get experience from starting from square one. Stem cells can be used to start from square one.

Anyway your idea seems right as well. :smile:
 
Olfactory neurons are continuously replaced throughout human life.
 

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