Error measuring glucose optical sensor

In summary, the group has designed an optical sensor using phosphorescence and glucose oxidase technology to measure glucose concentrations. However, they have encountered difficulties in observing different lifetime concentrations. In order to find a solution, they need more information on variables such as the range and absolute magnitude of glucose concentrations, the measurable variables and their relative magnitude, measurement methods, noise level, and the concept of lifetime concentrations and changes. Additionally, a sketch of the sensor and test setup would be helpful. Some suggested resources for further research are provided.
  • #1
niloofar
1
0
Hello
We have designed an optical sensor to measure glucose.
But we do not have the same changes for different concentrations. What do we need to do to be able to observe different Lifetime concentrations?
In our sensor test, we used phosphorescence and glucose oxidase technology. The sensor is located in 3 ml of PBS and some glucose is added each time. We can see Lifetime changes, but these changes are sometimes incremental and sometimes decreasing for different concentrations.
Does anyone have a solution to our problem?
 
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  • #2
We need much more information in order to help you.
1) What is PBS?
2) What range of glucose concentration?
3) What measurable variables change with glucose concentration?
4) What is the absolute magnitude of those variables?
5) What is the relative magnitude of those variables?
6) How are you measuring those variables?
7) What is the noise level?
8) What do mean by Lifetime concentrations and changes?
9) And a sketch of your sensor and test setup.
 
  • #3
niloofar said:
But we do not have the same changes for different concentrations.
Same changes of what?. Different concentrations of what?
You need tobe much more explicit aaaand detailed here.
 
  • #4
Way out of my field, but a Google search found the following:

When glucose oxidase is stimulated with various light wavelengths from UV to visible Blue, it will fluoresce somewhat. For some approaches, the hard part is the response-versus-concentration graph has an inflection point, so a reading can be mapped to at least two different concentrations. Also, some of the fluorescent lifetimes are in the ten's of nanoSeconds.

​

These articles may be of some use:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943336/
https://www.mdpi.com/2079-6374/10/8/86
https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.415.2233&rep=rep1&type=pdf

(above, and many more, found with:
https://www.google.com/search?q=phosphorescence+and+glucose+oxidase)

Please let us know what you find and how your research is progressing.

Thanks,
Tom
 

1. How accurate is the glucose optical sensor?

The accuracy of a glucose optical sensor can vary depending on the specific sensor and its calibration. However, most sensors have an accuracy range of around 10-20% compared to traditional blood glucose meters. It is important to regularly calibrate and verify the readings of the sensor to ensure accuracy.

2. How does the glucose optical sensor work?

The glucose optical sensor uses a light source and a photodetector to measure the amount of light that passes through a sample of blood. Glucose molecules in the blood absorb light at a specific wavelength, and the sensor uses this information to calculate the glucose concentration in the sample.

3. Can the glucose optical sensor be used for all types of diabetes?

The glucose optical sensor is typically designed for use with type 1 and type 2 diabetes. However, it may not be suitable for all individuals with these types of diabetes. It is important to consult with a healthcare professional to determine if a glucose optical sensor is the best option for managing your diabetes.

4. Are there any factors that can affect the accuracy of the glucose optical sensor?

There are several factors that can affect the accuracy of a glucose optical sensor, including temperature, humidity, and the quality of the blood sample. It is important to follow the manufacturer's instructions for proper use and storage of the sensor to ensure accurate readings.

5. How often should the glucose optical sensor be replaced?

The lifespan of a glucose optical sensor can vary depending on the specific sensor and its usage. Some sensors may need to be replaced every 7-14 days, while others may last up to several months. It is important to follow the manufacturer's instructions for replacing the sensor and to monitor its performance regularly.

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