Medical Ion Proton 1: A Chemical Engineer's Dream

AI Thread Summary
The Ion Proton 1, developed by Jonathan Rothberg, offers a groundbreaking advancement in DNA sequencing, capable of sequencing most of the human genome for approximately $1,000, a significant reduction from previous costs in the millions. The discussion also highlights IBM's development of a sequencer that may further reduce costs to around $100, utilizing a technology that reads DNA bases as they flow through holes on its surface. Additionally, the MinION sequencer is noted for its ability to read 150 million base pairs in just six hours, although its operational life is limited to that timeframe. The potential for nanopore sequencing technology to become affordable and reusable is emphasized, particularly for ecological applications where researchers could collect and analyze numerous samples in the field. The conversation reflects excitement about the future of affordable and accessible DNA sequencing technologies.
Biosyn
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What do you guys think of the Ion Proton 1 developed by a chemical engineer named Jonathan Rothberg? It can supposedly sequence most of a human genome for around $1000 compared to the past where had it costed millions.

I don't recall quite clearly, but I think researchers at IBM are developing a sequencer that costs around $100 that can read the bases of DNA fragments that flow through holes on its surface.



P.S.
Could someone please provide me with more references? I might write an essay on the Ion Proton sequencer. Thanks!


Sauce:
http://www.ncbi.nlm.nih.gov/pubmed/21776081

http://www.wired.com/wiredscience/2011/07/how-accurate-is-the-new-ion-torrent-genome-really/
 
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Here's the min-ion. Can do 150 million base pairs in 6 hours on a usb stick:

http://www.wired.co.uk/news/archive/2012-02/20/minion-dna-sequencer
 
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Pythagorean said:
Here's the min-ion. Can do 150 million base pairs in 6 hours on a usb stick:

http://www.wired.co.uk/news/archive/2012-02/20/minion-dna-sequencer

Impressive :)
$900
Is it one time use? There are over 2.9 billion base pairs in the human genome.
The operational life of the MinION is only about six hours, but during that time it can read more than 150 million base pairs.
Thank you!
 
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Biosyn said:
Impressive :)
$900
Is it one time use? There are over 2.9 billion base pairs in the human genome.!
IIRC it's stackable as well though I may be thinking of something else. It's about time nanopore sequencing started taking off, it's been "only five years away" for decades. What will be interesting is when it is cheap enough and reusable enough for ecologists to simply wander out into the field, spend a day collecting hundreds of samples from plants, soil, water, insects, animals etc then leave them all running overnight to sequence them.
 
https://www.discovermagazine.com/the-deadliest-spider-in-the-world-ends-lives-in-hours-but-its-venom-may-inspire-medical-miracles-48107 https://en.wikipedia.org/wiki/Versutoxin#Mechanism_behind_Neurotoxic_Properties https://www.sciencedirect.com/science/article/abs/pii/S0028390817301557 (subscription or purchase requred) The structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel...

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