Intuitively, you can think of the derivative as indicating how "steep" the function is.
Suppose you have a function F(x) and you pick some particular x. Then you can graph the function and draw the tangent line at x to that function. This tangent line tells you how steep the function is (if you zoom in far enough, the function and the tangent line will coincide). Now you can calculate the slope of the tangent line just as you would with any line, just calculate a vertical difference and divide it by the horizontal difference:
\operatorname{[Slope\ of\ F]}(x) = \frac{\Delta y}{\Delta x} = \frac{F(x + \Delta x) - F(x)}{(x + \Delta x) - x}
Draw a picture and try to identify the components of that equation (I can't do it on this forum, unfortunately).
Of course, it doesn't matter how big \Delta x is. The point is just, that as you make it smaller, the function looks more and more like the tangent line (that is, as you "zoom in" on the function it looks more and more like a straight line, which is the tangent line by construction, if you will) and therefore, the smaller you make \Delta x, the better the slope of the function (which is what the function above gives) and the slope of the tangent line (which is what you want to calculate) match. Mathematically, this means that we take the limit of \Delta x \to 0 in the above expression.
Derivatives, as the slope of a function, are an indication of how fast the function changes. If it is locally constant (like at the top of a parabola) then the derivative is zero. If the function is climbing at that point, the derivative is positive (and it's value tells you how steeply it climbs), if it is descending, the derivative is negative. This is very important information and you will find it anywhere. Most notably, in physics, if you have a function x(t) that describes the position of something as a function of time, the derivative will give you the velocity ("how fast the position changes") and the derivative of the velocity will give you the acceleration ("how fast the velocity changes").
I hope that made sense to you (I can't draw pictures here, that's too bad) -- try to draw some pictures yourself, hopefully that will make it clear what I am talking about.