A frame of reference in uniform circular motion is generally not considered inertial due to the presence of centripetal acceleration. Observers on a rotating frame, like a turntable, experience non-inertial effects such as centrifugal and Coriolis forces, confirming their frame's non-inertial status. However, if the circular motion is due to gravity, as in the case of an orbiting space capsule, the frame can approximate an inertial frame for local observations. The discussion highlights that while rotating frames can be useful in classical physics, they are not truly inertial. Understanding the context of the motion is crucial for determining the frame's inertial characteristics.