The moment of inertia of a body is minimized when rotating about its center of mass, as this axis minimizes the average distance of mass elements from the axis. While the mass remains constant regardless of the rotation axis, the distribution of mass affects the moment of inertia due to the squared distance factor in the calculation. The parallel axis theorem explains that rotating about an axis not through the center of mass increases the average distance to mass elements, thus increasing the moment of inertia. Practical examples, such as rotating a baseball bat, illustrate how different axes of rotation require varying amounts of effort, with the minimum effort occurring at the center of mass. Understanding these principles is crucial for accurately calculating moment of inertia in physical systems.