Antigen Rules in Human Immune System

In summary, antigens in the human immune system are statically floating around in the blood until they are eaten by Tcells. These antigens have a specific identity that allows Tcells to recognize them. Tcells are also able to identify and kill malfunctioning Tcells based on the proteins expressed on their surface. The body must encounter an antigen at least once in order to produce specific antibodies, but some cells have receptors that can recognize patterns found on pathogens.
  • #1
Craps
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Can you tell me what general rules does antigen have in human immune system ? I assume it is statically floating around in our blood till it is eaten by Tcells.
I also just learned it has a specific identity such that Tcells can recognize it, but what is that specific identity ?
Second, Tcells kill other Tcells when the latters malfunction, but how the formers know their relatives are mafunctioning ?
Thank-you :wink:
 
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  • #2
It will depend on the location of entry of the antigen. If an antigen is ingested than immune system cells inside the intestinal track will react to it. The antigen move inside the blood usually when invading pathogen penetrated the mucosal layer of the skin.

As far as specificity goes, the body has to encounter the antigen at least one time in order to produce specific antibodies. However, some cells have receptor (Toll-like receptor) that recognized conserved protein or other compound patterns found on/in pathogens. These receptor are not specific but it will iniate an immune response.

T-cell can recognize "malfunctionning" cell based on the proteins expressed on the surface. In a nutshell, if the proteins do not match the "self" pattern than the cell is destroyed.
 
  • #3
Something like that is always loved.:wink:, thanks
 

Related to Antigen Rules in Human Immune System

1. What is an antigen?

An antigen is a substance that is recognized by the immune system as foreign and elicits an immune response. Antigens can be viruses, bacteria, parasites, or other foreign substances.

2. How does the human immune system recognize antigens?

The human immune system recognizes antigens through specialized immune cells called T and B cells. These cells have receptors that can bind to specific antigens, allowing the immune system to identify and respond to them.

3. What are the rules for antigen recognition in the human immune system?

The rules for antigen recognition in the human immune system are based on the specificity and diversity of T and B cell receptors. Each receptor can only bind to a specific antigen, and the immune system produces a diverse range of receptors to recognize a wide variety of antigens.

4. How does the human immune system respond to antigens?

When an antigen is recognized by the immune system, it triggers an immune response. This can include the activation of immune cells, such as T and B cells, and the production of antibodies to neutralize the antigen.

5. Can the human immune system develop tolerance to antigens?

Yes, the human immune system can develop tolerance to antigens through a process called immune tolerance. This allows the immune system to recognize and respond to harmful antigens while ignoring harmless ones, preventing unnecessary immune reactions.

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