Are platelets required for blood clotting?

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In summary, when there is a platelet disorder, clotting time is not affected because platelets are not involved in the extrinsic coagulation pathway. Platelets are required for blood clotting, but only in the secondary hemostasis process. When a fibrous mesh is formed, red blood cells and platelets can get stuck in it, contributing to the formation of a blood clot.
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In blood clotting disorders, clotting time is increased, but when there is plalete disorder clotting time is not affected. What is the reason for that. Aren't platelets required for blood clotting. Also when a fibrous mesh is formed, do red blood cells and platelets get stuck in it. Is it why blood clots. Thanks :smile:
 
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sameeralord said:
In blood clotting disorders, clotting time is increased, but when there is plalete disorder clotting time is not affected. What is the reason for that. Aren't platelets required for blood clotting. Also when a fibrous mesh is formed, do red blood cells and platelets get stuck in it. Is it why blood clots. Thanks :smile:

Platelets are activated in primary hemostasis to form an initial plug which becomes enmeshed in the fibrin clot as the coagulation cascade proceeds (secondary hemostasis). Platelet activation is initiated with the release of von Willibrand factor from damaged vessel walls.

Prothrombin time (INR) measures only the extrinsic coagulation pathway in vitro and is only meaningful relative to a standard control time. Both primary and secondary hemostasis are necessary to form a stable clot as far as I know.
 
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1. What are platelets and what is their role in blood clotting?

Platelets are small, colorless cell fragments found in the bloodstream. Their main function is to stop bleeding by forming blood clots.

2. How do platelets contribute to blood clotting?

Platelets are activated when there is damage to a blood vessel. They release chemicals and proteins that help other blood cells and proteins to form a clot, which stops the bleeding.

3. Can blood clot without platelets?

Yes, blood can still clot without platelets, but the process would be much slower and less effective. Platelets play a crucial role in the clotting process and their absence can lead to excessive bleeding.

4. What happens if there are too many or too few platelets?

If there are too few platelets, it can result in a condition called thrombocytopenia, which can cause excessive bleeding. On the other hand, too many platelets can lead to blood clots, which can block blood flow and cause serious health problems.

5. How are platelet levels measured and maintained?

Platelet levels are measured through a blood test called a complete blood count (CBC). To maintain healthy platelet levels, it is important to have a balanced diet, exercise regularly, and avoid certain medications and activities that may increase the risk of bleeding or clotting.

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