ATP in Fatty acid oxidation and citric acid cycle

AI Thread Summary
ATP is utilized during fatty acid activation in beta-oxidation, specifically when a fatty acid reacts with ATP to form acyl adenylate, which consumes one ATP molecule. The second ATP equivalent is accounted for in the hydrolysis of pyrophosphate (PPi) to two inorganic phosphates (2Pi), effectively making it a two ATP cost process. In the citric acid cycle, ATP is produced when succinyl CoA is converted to succinate, generating GTP, which can be converted to ATP. The discussion also touches on the degradation of odd-chain fatty acids, noting that the final product, propionyl CoA, requires further processing. Understanding these ATP requirements is crucial for comprehending energy metabolism in fatty acid oxidation and the citric acid cycle.
jenzao
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At what point in either beta-oxidation or citric acid cycle is ATP used?
I see where ATP is produced in citric acid cycle (originally as GTP) as when succinyl CoA is converted to Succinate, but I can't find any part where ATP is required. Apparently according to my lecture notes, it is required during beta oxidation somewhere but I can't see exactly where? Please help, thanks!

UPDATE: i found out that the 2 ATP are used during fatty acid activtion, but I only see where one is required. (??)

(when fatty acid is added to 1 ATP to form acyladenylate) Where is other one required?? thanks
 
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jenzao said:
At what point in either beta-oxidation or citric acid cycle is ATP used?
I see where ATP is produced in citric acid cycle (originally as GTP) as when succinyl CoA is converted to Succinate, but I can't find any part where ATP is required. Apparently according to my lecture notes, it is required during beta oxidation somewhere but I can't see exactly where? Please help, thanks!

UPDATE: i found out that the 2 ATP are used during fatty acid activtion, but I only see where one is required. (??)

(when fatty acid is added to 1 ATP to form acyladenylate) Where is other one required?? thanks
Could the question be referring to the hydrolysis of the resulting pyrophosphate?

Fatty acid + ATP <-----> Acyl adenylate + PPi
PPi + pyrophosphatase -------> 2Pi

What about odd number fatty acid degradation? How is the final product (propionyl CoA) dealt with?
 
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