To find the coefficient of p^4q^7 in the expansion of (2p-q)(p+q)^10, the binomial expansion theorem is essential. Users discuss the need to expand (p+q)^10 and then multiply the resulting terms to isolate p^4q^7. There is some confusion regarding the correct method of expansion, with one user clarifying that (2p-q)(p+q) cannot be simplified as suggested. The conversation emphasizes understanding the binomial expansion to avoid unnecessary complexity in calculations. Overall, the thread highlights the importance of mastering binomial expansion for solving such problems effectively.