I think the OP means a system modeled as point masses connected by rigid massless rods.
If your mechanics course covered bending of beams, you know about the idea of "principal axes" for a beam cross section. Any arbitrary shape has two principal axes at right angles such that the cross-product of area is zero, i.e. ##\int xy\,dA = 0##. If you apply a force along one of the principal axes, the beam bends in the same direction as the force. If you apply a force in a different direction, in general the beam does NOT bend in the same direction. You can deal with that by resolving the force into components along the principal axes and summing the displacements from each component.
The same idea applies to your system of particles. For any system, there will be a set of 3 orthogonal coordinate directions through the center of mass, such that all the cross-products of inertia are zero. If you resolve your applied moment into those three components, you can find the anguilar acceleration in each component direction and sum them.
But there is another complication that didn't arise in the beam problem: if your system will rotate through arbitrary large angles (i.e. it's not just vibrating with small amplitude about some fixed position) the directions of the principal axes will also change with time... and that's a good place to stop describing the situation in words, and say "read a dynamics textbook".
Of course if the moment starts off aligned with just one of the principal axes, the system rotates about that axis and that axis does not change direction, so things are much simpler - and that's probably the only case you will meet in a first dynamics course (Redbelly's bicyvle wheel, for example)
A "not quite so simple" example is a gyroscope, where the angular acceleration depends not only on the applied moment, but also on the motion of the system (i.e. on the speed of rotation of the gyro).